Molecular epidemiology of hepatitis B virus infection in Tanzania.
Identifieur interne : 000524 ( Main/Exploration ); précédent : 000523; suivant : 000525Molecular epidemiology of hepatitis B virus infection in Tanzania.
Auteurs : Joseph C. Forbi [États-Unis] ; Michael Dillon [Tanzanie] ; Michael A. Purdy [États-Unis] ; Bakary S. Drammeh [Tanzanie] ; Alexandra Tejada-Strop [États-Unis] ; Daniel Mcgovern [États-Unis] ; Guo-Liang Xia [États-Unis] ; Yulin Lin [États-Unis] ; Lilia M. Ganova-Raeva [États-Unis] ; David S. Campo [États-Unis] ; Hong Thai [États-Unis] ; Gilberto Vaughan [États-Unis] ; Dunstan Haule [Tanzanie] ; Regina P. Kutaga [Tanzanie] ; Sridhar V. Basavaraju [Tanzanie] ; Saleem Kamili [États-Unis] ; Yury E. Khudyakov [États-Unis]Source :
- The Journal of general virology [ 1465-2099 ] ; 2017.
Abstract
Despite the significant public health problems associated with hepatitis B virus (HBV) in sub-Saharan Africa, many countries in this region do not have systematic HBV surveillance or genetic information on HBV circulating locally. Here, we report on the genetic characterization of 772 HBV strains from Tanzania. Phylogenetic analysis of the S-gene sequences showed prevalence of HBV genotype A (HBV/A, n=671, 86.9 %), followed by genotypes D (HBV/D, n=95, 12.3 %) and E (HBV/E, n=6, 0.8 %). All HBV/A sequences were further classified into subtype A1, while the HBV/D sequences were assigned to a new cluster. Among the Tanzanian sequences, 84 % of HBV/A1 and 94 % of HBV/D were unique. The Tanzanian and global HBV/A1 sequences were compared and were completely intermixed in the phylogenetic tree, with the Tanzanian sequences frequently generating long terminal branches, indicating a long history of HBV/A1 infections in the country. The time to the most recent common ancestor was estimated to be 188 years ago [95 % highest posterior density (HPD): 132 to 265 years] for HBV/A1 and 127 years ago (95 % HPD: 79 to 192 years) for HBV/D. The Bayesian skyline plot showed that the number of transmissions 'exploded' exponentially between 1960-1970 for HBV/A1 and 1970-1990 for HBV/D, with the effective population of HBV/A1 having expanded twice as much as that of HBV/D. The data suggest that Tanzania is at least a part of the geographic origin of the HBV/A1 subtype. A recent increase in the transmission rate and significant HBV genetic diversity should be taken into consideration when devising public health interventions to control HBV infections in Tanzania.
DOI: 10.1099/jgv.0.000776
PubMed: 28537543
Affiliations:
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Forbi</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Dillon, Michael" sort="Dillon, Michael" uniqKey="Dillon M" first="Michael" last="Dillon">Michael Dillon</name><affiliation wicri:level="1"><nlm:affiliation>2CDC Tanzania, Division of Global HIV/AIDS, Center for Global Health, Centers for Disease Control and Prevention, Dar es Salaam, Tanzania.</nlm:affiliation><country xml:lang="fr">Tanzanie</country><wicri:regionArea>2CDC Tanzania, Division of Global HIV/AIDS, Center for Global Health, Centers for Disease Control and Prevention, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Purdy, Michael A" sort="Purdy, Michael A" uniqKey="Purdy M" first="Michael A" last="Purdy">Michael A. Purdy</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Drammeh, Bakary S" sort="Drammeh, Bakary S" uniqKey="Drammeh B" first="Bakary S" last="Drammeh">Bakary S. Drammeh</name><affiliation wicri:level="1"><nlm:affiliation>3HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, CDC, Dar es Salaam, Tanzania.</nlm:affiliation><country xml:lang="fr">Tanzanie</country><wicri:regionArea>3HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, CDC, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Tejada Strop, Alexandra" sort="Tejada Strop, Alexandra" uniqKey="Tejada Strop A" first="Alexandra" last="Tejada-Strop">Alexandra Tejada-Strop</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Mcgovern, Daniel" sort="Mcgovern, Daniel" uniqKey="Mcgovern D" first="Daniel" last="Mcgovern">Daniel Mcgovern</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Xia, Guo Liang" sort="Xia, Guo Liang" uniqKey="Xia G" first="Guo-Liang" last="Xia">Guo-Liang Xia</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lin, Yulin" sort="Lin, Yulin" uniqKey="Lin Y" first="Yulin" last="Lin">Yulin Lin</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ganova Raeva, Lilia M" sort="Ganova Raeva, Lilia M" uniqKey="Ganova Raeva L" first="Lilia M" last="Ganova-Raeva">Lilia M. Ganova-Raeva</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Campo, David S" sort="Campo, David S" uniqKey="Campo D" first="David S" last="Campo">David S. Campo</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Thai, Hong" sort="Thai, Hong" uniqKey="Thai H" first="Hong" last="Thai">Hong Thai</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Vaughan, Gilberto" sort="Vaughan, Gilberto" uniqKey="Vaughan G" first="Gilberto" last="Vaughan">Gilberto Vaughan</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Haule, Dunstan" sort="Haule, Dunstan" uniqKey="Haule D" first="Dunstan" last="Haule">Dunstan Haule</name><affiliation wicri:level="1"><nlm:affiliation>4Tanzania National Blood Transfusion Services, Ministry of Health and Social Welfare, Dar es Salaam, Tanzania.</nlm:affiliation><country xml:lang="fr">Tanzanie</country><wicri:regionArea>4Tanzania National Blood Transfusion Services, Ministry of Health and Social Welfare, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Kutaga, Regina P" sort="Kutaga, Regina P" uniqKey="Kutaga R" first="Regina P" last="Kutaga">Regina P. Kutaga</name><affiliation wicri:level="1"><nlm:affiliation>5US Centers for Disease Control and Prevention, Dar es Salaam, Tanzania.</nlm:affiliation><country xml:lang="fr">Tanzanie</country><wicri:regionArea>5US Centers for Disease Control and Prevention, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Basavaraju, Sridhar V" sort="Basavaraju, Sridhar V" uniqKey="Basavaraju S" first="Sridhar V" last="Basavaraju">Sridhar V. Basavaraju</name><affiliation wicri:level="1"><nlm:affiliation>3HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, CDC, Dar es Salaam, Tanzania.</nlm:affiliation><country xml:lang="fr">Tanzanie</country><wicri:regionArea>3HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, CDC, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Kamili, Saleem" sort="Kamili, Saleem" uniqKey="Kamili S" first="Saleem" last="Kamili">Saleem Kamili</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Khudyakov, Yury E" sort="Khudyakov, Yury E" uniqKey="Khudyakov Y" first="Yury E" last="Khudyakov">Yury E. Khudyakov</name><affiliation wicri:level="2"><nlm:affiliation>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of general virology</title><idno type="eISSN">1465-2099</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the significant public health problems associated with hepatitis B virus (HBV) in sub-Saharan Africa, many countries in this region do not have systematic HBV surveillance or genetic information on HBV circulating locally. Here, we report on the genetic characterization of 772 HBV strains from Tanzania. Phylogenetic analysis of the S-gene sequences showed prevalence of HBV genotype A (HBV/A, n=671, 86.9 %), followed by genotypes D (HBV/D, n=95, 12.3 %) and E (HBV/E, n=6, 0.8 %). All HBV/A sequences were further classified into subtype A1, while the HBV/D sequences were assigned to a new cluster. Among the Tanzanian sequences, 84 % of HBV/A1 and 94 % of HBV/D were unique. The Tanzanian and global HBV/A1 sequences were compared and were completely intermixed in the phylogenetic tree, with the Tanzanian sequences frequently generating long terminal branches, indicating a long history of HBV/A1 infections in the country. The time to the most recent common ancestor was estimated to be 188 years ago [95 % highest posterior density (HPD): 132 to 265 years] for HBV/A1 and 127 years ago (95 % HPD: 79 to 192 years) for HBV/D. The Bayesian skyline plot showed that the number of transmissions 'exploded' exponentially between 1960-1970 for HBV/A1 and 1970-1990 for HBV/D, with the effective population of HBV/A1 having expanded twice as much as that of HBV/D. The data suggest that Tanzania is at least a part of the geographic origin of the HBV/A1 subtype. A recent increase in the transmission rate and significant HBV genetic diversity should be taken into consideration when devising public health interventions to control HBV infections in Tanzania.</div></front></TEI><affiliations><list><country><li>Tanzanie</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Forbi, Joseph C" sort="Forbi, Joseph C" uniqKey="Forbi J" first="Joseph C" last="Forbi">Joseph C. Forbi</name></region><name sortKey="Campo, David S" sort="Campo, David S" uniqKey="Campo D" first="David S" last="Campo">David S. Campo</name><name sortKey="Ganova Raeva, Lilia M" sort="Ganova Raeva, Lilia M" uniqKey="Ganova Raeva L" first="Lilia M" last="Ganova-Raeva">Lilia M. Ganova-Raeva</name><name sortKey="Kamili, Saleem" sort="Kamili, Saleem" uniqKey="Kamili S" first="Saleem" last="Kamili">Saleem Kamili</name><name sortKey="Khudyakov, Yury E" sort="Khudyakov, Yury E" uniqKey="Khudyakov Y" first="Yury E" last="Khudyakov">Yury E. Khudyakov</name><name sortKey="Lin, Yulin" sort="Lin, Yulin" uniqKey="Lin Y" first="Yulin" last="Lin">Yulin Lin</name><name sortKey="Mcgovern, Daniel" sort="Mcgovern, Daniel" uniqKey="Mcgovern D" first="Daniel" last="Mcgovern">Daniel Mcgovern</name><name sortKey="Purdy, Michael A" sort="Purdy, Michael A" uniqKey="Purdy M" first="Michael A" last="Purdy">Michael A. Purdy</name><name sortKey="Tejada Strop, Alexandra" sort="Tejada Strop, Alexandra" uniqKey="Tejada Strop A" first="Alexandra" last="Tejada-Strop">Alexandra Tejada-Strop</name><name sortKey="Thai, Hong" sort="Thai, Hong" uniqKey="Thai H" first="Hong" last="Thai">Hong Thai</name><name sortKey="Vaughan, Gilberto" sort="Vaughan, Gilberto" uniqKey="Vaughan G" first="Gilberto" last="Vaughan">Gilberto Vaughan</name><name sortKey="Xia, Guo Liang" sort="Xia, Guo Liang" uniqKey="Xia G" first="Guo-Liang" last="Xia">Guo-Liang Xia</name></country><country name="Tanzanie"><noRegion><name sortKey="Dillon, Michael" sort="Dillon, Michael" uniqKey="Dillon M" first="Michael" last="Dillon">Michael Dillon</name></noRegion><name sortKey="Basavaraju, Sridhar V" sort="Basavaraju, Sridhar V" uniqKey="Basavaraju S" first="Sridhar V" last="Basavaraju">Sridhar V. Basavaraju</name><name sortKey="Drammeh, Bakary S" sort="Drammeh, Bakary S" uniqKey="Drammeh B" first="Bakary S" last="Drammeh">Bakary S. Drammeh</name><name sortKey="Haule, Dunstan" sort="Haule, Dunstan" uniqKey="Haule D" first="Dunstan" last="Haule">Dunstan Haule</name><name sortKey="Kutaga, Regina P" sort="Kutaga, Regina P" uniqKey="Kutaga R" first="Regina P" last="Kutaga">Regina P. Kutaga</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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